How do mitochondrial function and signaling regulate cellular functions, physiology, and human disease?

The Haigis laboratory focuses on the molecular regulation of mitochondrial functions during aging and age-related disease. Our goal is to investigate how pathways that control aging, such as sirtuins, impact mitochondrial fuel utilization, bioenergetics and signaling. To achieve these objectives, we take a multidisciplinary approach that employs biochemical, cellular, and mouse modeling experiments to systematically dissect the mitochondrial pathways of interest.