Giulia completed her undergraduate studies at Mount Holyoke College. After graduating, she spent two years at the NIH in the lab of Michael Lenardo, working on understanding the molecular mechanisms that control cellular responses, and how defects in such responses may lead to diseases of the immune system. She is currently interested in characterizing tumor-immune metabolic interactions in the tumor microenvironment.
Jefte's work, mentored by Marcia Haigis and Arlene Sharpe, focuses on the metabolic regulation of T cell functionality, particularly in the context of immune responses against cancer. He is supported by a fellowship from the National Institutes of Health.
Has a love-hate relationship with: chocolate (it's complicated).
I am interested in the adaptive reprogramming of cancer cells under the selective pressure imposed by therapeutics that enriches the microenvironment with resistant cells. Specifically, I am interested in understanding the metabolic requirements that support this transition. My work is supported by the National Science Foundation Grad
I’m interested in studying the role of mitochondrial sirtuins in governing mitochondrial fate from a quality control viewpoint. My work is supported by a PhD grant from the Portuguese Foundation for Science and Technology (FCT).
My project focuses on the role of mitochondrial sirtuins on glutamine metabolism. Like Natalie, I am in the Biological and Biomedical Sciences Program at HMS. I enjoy spending time with friends and family. I also like to dance, travel, crochet, learn new languages, and I am open to trying and learning new things. My work is supported by The Paul & Daisy Soros Fellowship for New Americans.
Jaewon is studying the pathways that (mitochondrial) sirtuins regulate in response to various cell stress signals. He is currently attending Tufts University School of Medicine, has received a summer Proctor Program Award, and is supported by a HHMI Medical Research Fellows Program received in 2012.
Having completed his PhD in our lab on the regulation of SIRT3 expression, Kyle is currently conducting a small molecule screen for activators of mitochondrial function. His work is supported by the Blavatnik Biomedical Accelerator.
I recently completed my PhD in the Haigis lab with a dissertation focused on identifying and exploiting metabolic vulnerabilities in cancer. Now as a post-doc, I am finishing my research on nutrient utilization and metabolic liabilities in acute myeloid leukemia.
Lydia is interested in understanding how lysine acetylation affects mitochondrial function. To do this, she is using SIRT3 KO mice under a variety of nutritional and metabolic stresses in order to identify mitochondrial proteins and pathways that are regulated by reversible acetylation as well as the pathological implications of dysregulation of mitochondrial acetylation.
Lydia is in the BBS program at HMS and is supported by the National Science Foundation Graduate Research Fellowship.
Alexandra is interested in understanding the effects of sirtuins on the regenerative potential of skeletal muscle stem cells. She is enrolled in the GSAS Visiting Fellows Program and supported by the German Academic Exchange Service Ph.D. Fellowship.