Lab Members

Principal Investigator
Marcia Haigis

Marcia Haigis, PhD

Professor
Department of Cell Biology
Harvard Medical School
LHRRB Room 301A
240 Longwood Avenue
Boston, MA 02115

Phone: 617-432-6865
Fax: 617-432-6932
marcia_haigisathms.harvard.edu

Marcia C. Haigis, Ph.D., is a Professor in the Department of Cell Biology at Harvard Medical School in Boston, MA,  a member of the Paul F. Glenn Center for the Biology of Aging, and the Ludwig  Center at Harvard Medical School. Following graduate training in Biochemistry at the University of Wisconsin-Madison in Biochemistry, Dr. Haigis studied mitochondrial metabolism during her postdoctoral research at MIT. She has contributed to understanding the role that mitochondrial sirtuins play in metabolism and disease. She has received a number of honors, including the Ellison Medical Foundation New Scholar Award, the Brookdale Foundation Leadership in Aging Award, and selection for the National Academy of Medicine's Emerging Leaders in Health and Medicine Program. 

Mass Spectrometry Director and Lab Manager
Shakchhi Joshi

Shakchhi Joshi

Harvard Medical School
240 Longwood Avenue
Boston, MA 02115

shakchhi_joshiathms.harvard.edu

Shakchhi graduated from Creighton University with a bachelor's degree in Neuroscience and Psychology. As the Mass Spectrometry Director, she oversees instrument maintenance, coordinates run schedules, and provides supervision and training to lab members and collaborators across various scientific projects encompassing immunology, metabolism, oncology, neurology, and more, on three of the lab's LC-MS mass spectrometry instruments. As the Lab Manager, she is responsible for training new technicians, onboarding lab members, coordinating events, and overseeing inspections and lab safety protocols.

Known Aliases: Sha, Shakichi, Shak, Shakira, Joshi

Favorite Food: Momo 

Postdoctoral Fellows
Jamie Brett

Jamie Brett

jamie_obrettatdfci.harvard.edu

Jamie grew up in the Bay Area, Northern CA, where her high school biology teacher got her to read Loren Eiseley ("The Snout") and set her on the biology research path. Jamie went to Stanford for her undergraduate, where she worked in Anne Brunet’s lab on neural stem cell aging. She stayed at Stanford for her MD/PhD, and in Tom Rando’s lab she investigated skeletal muscle stem cell quiescence, aging, and rejuvenation by exercise. Jamie then traveled to Boston for residency at MGH and Heme/Onc fellowship at MGH/BWH/DFCI. She is interested in sarcomas and metabolism.

Fun fact: All of my dogs have had the same name!

Portrait

James Han

seongjun_hanathms.harvard.edu

James is a co-mentored post-doctoral fellow in Drs. Marcia Haigis and Arlene Sharpe laboratories. He completed his BSc at McMaster University, and MSc and PhD at the University of Toronto. Under the supervision of Dr. Pamela Ohashi and mentorship/guidance from Drs. Tak Mak and Naoto Hirano, his doctoral research focused on developing strategies to overcome T cell tolerance in the tumor microenvironment. James joined the Haigis and Sharpe labs to further understand how tumor microenvironment and anti-tumor immunity change with aging. 

Favorite Food: K-bbq, KFC (Korean Fried Chicken), sushi 

Hobbies: investing (stocks, crypto, etc) & travelling

Portrait

Ji Seul Han

jiseul_hanathms.harvard.edu

Ji Seul completed his Ph.D at Seoul National University in the lab of Jae Bum Kim. In his doctoral research, he investigated roles of HIF in the regulation of lipid catabolism and thermogenesis in adipocytes. Ji Seul is interested in studying how adipocytes sense and control metabolites upon metabolic diseases.

Hobbies: Cooking, traveling

Portrait

Annie Hsieh

annie_hsiehathms.harvard.edu

Annie is co-mentored post-doctoral fellow in Drs. Marcia Haigis and Bernardo Sabatini laboratories. She completed her M.D. at Tzu Chi University in Taiwan and then she pursued her Ph.D. at Johns Hopkins University under the supervision of Dr. Chi Dang, where she studied MYC disruption of molecular clock in cancer cells. In collaboration with Dr. Amita Sehgal, she also found drosophila Myc is required in maintaining circadian behavior and metabolism in fruit flies. She then completed her neurology residency at Albert Einstein Medical Center in Philadelphia and matched into the neuro-oncology fellowship program at MGH/DFCI/BWH. Annie is particularly interested in studying the mechanism of metabolic regulation of neurotransmitters in glioma.  

Hobbies: traveling, skiing, and trying interesting restaurants 

My childhood dream: Becoming a congresswoman 

Portrait

Songhua Hu

songhua_huathms.harvard.edu

Songhua completed his Ph.D at Fudan University in the lab of Shimin Zhao, studying how metabolites regulates metabolism through forming covalent modification to proteins. During his Ph.D, he found a novel protein lipidation, namely tryptophan polyunsaturated fatty-acylation. In his post-doc, Songhua is more interested in immunometabolism, and he also maintains a great interest in SIRT4, the last puzzle of mitochondrial Sirtuins.

 

Favorite Food: Hot Pot, sushi

Favorite Movie & Actors: King of Comedy, Stephen Chow

Kiran Kurmi, PhD

kiran_kurmiathms.harvard.edu

Kiran completed his Ph.D at Mayo Clinic in the lab of Taro Hitosugi, studying how oncogenic signals modulate mitochondrial metabolism. Kiran's current work focuses on areas of immunometabolism, primarily investigating various cell-intrinsic metabolic processes that can influence the performance of immune cell function with the goal of exploiting these alterations for clinical intervention. Kiran is a Gilead Sciences fellow of the Life Sciences Research Foundation

Favorite food: chicken chihuahua from Taco Bell

 

Image

Zongyu Li

zongyu_liathms.harvard.edu

Zongyu was born in Tianjin, China, and he believes that Tianjin has the best breakfast in the world. He completed his undergraduate degree at Tsinghua University in Beijing and his Ph.D. at Yale University as the first student in Dr. Rachel Perry’s Lab. He joined Haigis Lab because he is interested in LC/MS-based metabolomics, and he wants to apply this technique to various types of lymphocytes. 

Fun Fact: Zongyu is a black belt holder in Taekwondo, but now he totally forgets how to use this martial art.

Jaime Schneider, MD/PhD

Jaime_Schneideratdfci.harvard.edu

Jaime was born and raised in Florida, completed her undergraduate degree in Biochemistry at Northwestern University, and her MD and PhD degrees at Albert Einstein College of Medicine. After training in internal medicine at MGH, she matriculated into the hematology/oncology fellowship program at DFCI and is particularly interested in thoracic oncology. She joined the Haigis lab to study mechanisms of metabolic and proteostasis dysregulation in cancer and the interplay between oncogenesis and aging. 

Spirit animal: The Dachshund 

Conghui Yao, PhD

Conghui_Yaoathms.harvard.edu

Conghui completed her PhD at Washington University in St. Louis, where she worked on LC/MS based metabolomics of cancer cells. In her postdoc, Conghui is interested in studying how immune cell functions are comprised in the tumor microenvironment.

Interested in but not good at: basketball 

Graduate Students
Image

Hyunji An

hyunjianatg.harvard.edu

Hyunji is a Ph.D. student in the BBS program and is co-mentored between Drs. Marcia Haigis and Miao Cui laboratories. Born and raised in South Korea, she completed her BSc and MSc at University of Seoul. She studied plasmonic nanoparticles for bio-sensing and bio-imaging during her master’s under the supervision of Dr. Inhee Choi. After that, she worked as a research trainee in the lab of Dr. Luke P. Lee at Harvard Medical School, where she developed her interest in biomedical research. She is currently interested in exploring heart regeneration from metabolic perspectives. Outside the lab, Hyunji writes books about city plants and enjoys bouldering, live music, playing board games, and being in nature. 

Fun fact: She majored in horticulture in undergrads, but her home plants never survive long. (Good with outside garden)

Portrait

Yutong Dai

yutong_daiatfas.harvard.edu

Yutong (Mary) received her bachelor’s degree from Massachusetts Institute of Technology. She did her undergraduate research in the Johnson Lab, working on antibody-polymer conjugates for cancer treatments. She is currently interested in integrating chemical methods to study metabolite signaling.

Hobbies: traveling, playing board game!

portrait

Peter Georgiev

peter_georgievathms.harvard.edu

Peter is a PhD student in the HMS Immunology program and is co-mentored between the Haigis and Sharpe laboratories. He is interested in understanding the metabolic determinants of effective anti-tumor immunity and metabolic usage of CD8T cells in the settings of cancer and aging. Previously Peter worked as an industry scientist at Merck Research Laboratories where he supported the pre-clinical development of several immunotherapeutic agents across the early discovery pipeline. In addition to immunometabolism, Peter is broadly interested in immune tolerance and cancer immunology.  When he is not doing science Peter enjoys spending time with his wife Tehya and daughter Sofia Belle.

Hobbies: Fishing

Favorite Food: Neapolitan Pizza

Portrait

Sheila Johnson

sheilajohnsonatfas.harvard.edu

Sheila received her B.S. in Biochemistry from University of Wisconsin-Madison. Her undergraduate research in the lab of Dave Pagliarini was focused on identifying enzymes and precursors involved in coenzyme Q biosynthesis. She is currently interested in exploring how alterations in T cell metabolism improve antitumor immunity. 

Favorite show: Avatar: The Last Airbender

portrait

Liam Kelley

liam_kelleyatg.harvard.edu

Liam did his undergraduate research in the laboratory of Bryan Ballif at University of Vermont, where he studied blood group systems. He is currently researching the interaction between tumor metabolism and urea cycle dysfunction in the context of hepatocellular carcinoma. In addition, he is interested in studying the contributions of proteomic changes to cancer metabolism.

Hobbies: Editing Wikipedia


Favorite protein: SrcASM

Visiting Graduate Student
Portrait

Christian Joschko

 

 

c.p.joschkoatumcg.nl

Christian is an enthusiastic MD/PhD student at the University Medical Center Groningen, Netherlands. He is deeply engaged in the study of mitochondrial function and metabolic processes. His fascination with mitochondria and metabolism was kindled in the lab of experimental pharmacology during his bachelor's degree, where he investigated the protective mechanisms in hibernating species against cold-induced stress. Under the supervision of Dr. Leo Deelman and Dr. Rob Henning, his PhD research delves into the role of transsulfuration and hydrogen sulfide signalling in aging and the development of metabolic diseases. Recently, Christian joined the Haigis lab to further his studies in mitochondrial biology, focusing on the metabolic shifts in proliferative cells during aging.

Hobbies: Cooking and Chess.

Fun fact: In his leisure time, Christian enjoys exploring small breweries in the area, maintaining a connection to his German culture and counterbalancing his scientific endeavors.

Research Assistants
Portrait

Joseph Crowley

joseph_crowleyathms.harvard.edu

Joe graduated with a BA in Biology with a Minor in Environmental Studies from College of the Holy Cross. As a research assistant in the lab, his focus is on mass spectrometry. He also assists multiple postdocs in their research through bench work and analysis, works as an animal technician, as well as other administrative duties.

Favorite Food: Squirrel

Hobbies: Archery, bicycling, hunting.

Photo

Madiha Irshad

madiha_irshadathms.harvard.edu

Madiha graduated from Williams College with a BA in Biology and a concentration in Neuroscience. She collaborates with Dr. Annie Hsieh as a research assistant in the laboratory, investigating the metabolic regulation of neurotransmitters in glioma. She also spends part of her time working for the Sabatini lab.  

Hobbies: Watching true crime documentaries and online shopping  

Favorite Animal: Cats